| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Magnesium Technology 2025
|
| Presentation Title |
Computatinal modelling of Mg alloy biodegradation and bone growth |
| Author(s) |
Berit Zeller-Plumhoff, Tamadur AlBaraghtheh, Domenik Priebe, Nik Pohl, Sascha Trostorff, Ralf Köhl, Regine Willumeit-Römer |
| On-Site Speaker (Planned) |
Berit Zeller-Plumhoff |
| Abstract Scope |
Both in vitro and in vivo testing of biodegradable magnesium alloys are associated with high costs and time expenditure, as well as ethical concerns in the case of animal experiments. Therefore, computational modelling, may present a suitable alternative to perform in silico testing, once models with predictive capabilities have been established.
We have developed models of Mg-based alloy degradation using partial differential equations to enable a phenomenological description of the degradation process. To accelerate model calibration using experimental data and sensitivity analysis, we have established best practices to train surrogate models such as Kriging, polynomial chaos expansion, and polynomial chaos Kriging. For comparison, we have implemented simplified models using ordinary differential equations that have been established, which we have coupled further with models of bone growth surrounding the implant.
We will present the established workflow and results, highlighting the potential of computational modelling for in silico testing of Mg-based alloys. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Magnesium, Modeling and Simulation, Computational Materials Science & Engineering |