Recent advancements in manufacturing have provided unprecedented opportunities to produce materials with precisely defined architectures. This has in turn provided opportunities to achieve new combinations of material properties, including combinations of mechanical, thermal, and fluidic properties, enabling creation of multifunctional architected materials. These material structures may be static with constant properties, or dynamic with properties that change in time. To realize the potential of these capabilities, new designs and ultimately new design methods are required. The computational design tool of topology optimization is well-suited to address this new design challenge and explore the now expanded design space provided by architected materials. This talk will discuss the use of topology optimization in the design of multifunctional architected materials optimized for various combinations of properties, and discuss the integration of manufacturing considerations into the design process, ultimately leading to architected material designs that are both high performance and manufacturable.