Though lower fidelity than full-field crystal plasticity models, the computationally inexpensive viscoplastic self-consistent polycrystal plasticity model (VPSC) should excel in the high-throughput, rapid-iteration ICME paradigm. However, the text-file interface creates a steep learning curve, and lack of published automation tools for VPSC limits its potential value for ICME. The authors discuss development of a modern application programming interface (API) in MATLAB which streamlines user interaction and includes functionality for automating VPSC experiments. The MTEX toolbox—a library of MATLAB code for representing and transforming crystallographic, microstructural, and deformation data—is used as the exemplar for an easy-to-learn modern API, with a planned integration of the VPSC automation API into the MTEX toolbox for wider accessibility. To demonstrate the high-throughput capabilities, a case study will be presented that uses the VPSC automation API as part of an ICME strategy to optimize the energy efficiency of titanium alloy processing.