Nano-architectected metals can exploit the combination of resilient architecture with size-dependent enhanced properties at nanoscale to achieve exceptional mechanical performance. To obtain a mechanistic understanding of plastic deformation in these materials requires an integrated computational model which can capture the relation between dislocation microstructure characteristics and macroscopic mechanical behaviors. Recently, we develop a multi-scale model to concurrently couple dislocation dynamics (DD) modeling with finite element method (FEM). The DD simulation keeps track of dynamic motion of dislocations and compute the accompanying plastic strain, while FEM simulation solves for the stress field to satisfy equilibrium condition. By integrating these, our model could provide a unique opportunity to investigate fundamental deformation mechanism based on dislocation plasticity and corresponding macroscopic mechanical response. In this study, multi-scale simulations of meso-scale architected structures under uniaxial compression were performed. The architected structures exhibit increasing strength with decreasing unit cell size, which agrees with experimental observations.