Physics-based materials and process modeling has developed to a point where it is supporting the design and qualification of new components produced by additive manufacturing (AM). Focused models that describe various elements of the AM process, the evolution of microstructure and defects, and location-specific mechanical properties are key elements. Computational tools, when used as integrated modeling workflows, provide for a model-based definition framework for additive materials and processes. ICME property prediction starts with the thermal history, possibly at the scale of the individual melt pool or each layer if the local behavior is homogeneous. Examples will include spatial variation of geometry leading to variations in the local thermal history, microstructure, and properties in Ti-6Al-4V. Statistical description of microstructure provides statistically equivalent representative volume elements for predicting local mechanical properties. The alignment of model-guided testing and associated predicted properties can provide for a path to efficient and smart certification and qualification.