The benefits to industry in applying ICME are many, including a science-informed understanding of the challenges observed in material manufacturing, rapid optimization of chemistry and heat treatment, and an accelerated qualification of new materials enabling improved component performance. This presentation will exemplify how QuesTek has leveraged its ICME technologies to understand and worked to resolve the most pressing materials related issues to combine manufacturability and performance in various alloy systems. Emphasis will be placed on how QuesTek utilize expertise and interact with entities across the value chain, from producers and manufacturers to end-users, and in collaboration with research institutes and universities. This workflow inherently helps to bridge the gap between academia and industry. Technical examples from collaboration projects in Europe and USA will be presented, and general challenges discussed.