Sixty years of academic collaboration and thirty years of commercialization by a network of small businesses have delivered a mature technology of computational materials design and accelerated qualification grounded in the CALPHAD system of fundamental databases now known as the Materials Genome. The national Materials Genome Initiative acknowledging the reality of this technology has spurred global interest and rapid adoption by US apex corporations. Designed materials with broad market impact now span a range from consumer electronics to space exploration. Ongoing design addresses the new alloys enabling new manufacturing methods such as 3D printing as well as the materials supporting affordable approaches to sustainability. The advanced design and qualification software system, ICMDŽ, developed at QuesTek is now prepared for commercial application.