About this Abstract |
Meeting |
2024 TMS Annual Meeting & Exhibition
|
Symposium
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Printed Electronics and Additive Manufacturing: Advanced Functional Materials, Processing Concepts, and Emerging Applications
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Presentation Title |
Microstructural and Mechanical Analysis of Aerosol Jet 3D Printed Gold Micropillars and Their Biocompatibility in Mouse Brain |
Author(s) |
Sanjida Jahan, Chunshan Hu, Bin Yuan, Hailey Gorden, Sandra Ritchie, Eric Yttri, Rahul Panat |
On-Site Speaker (Planned) |
Sanjida Jahan |
Abstract Scope |
Microelectrode arrays are used for recording electrophysiological activity from brain tissue and spinal cord which helps to understand neural activities and diagnose and monitor neural diseases. Implantable neural probes consisting of gold electrodes have potential to record from the brain tissue with minimum infection and inflammation to the brain tissue. To penetrate the brain tissue and record from it, 3D gold electrodes require the necessary mechanical strength. In this work, we used Aerosol Jet nanoprinting to fabricate gold micropillars with aspect ratios of up to 10:1 and measure their behavior under uniaxial compression. After establishing the mechanical strength, the 4×8 array of 3D printed gold microelectrodes with 250 µm pitch, coated with Parylene-C except the tips, were implanted in mouse brains up to 6 weeks. Analyzing the brain slices after certain intervals, brain tissue shows minimal accumulation of astrocyte and microglia cell types between short-term and long-term observation periods. |
Proceedings Inclusion? |
Planned: |
Keywords |
Additive Manufacturing, Biomaterials, Mechanical Properties |