| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
3D Printing of Biomaterials and Devices
|
| Presentation Title |
Silica-Doped 3D Printed Scaffold Loaded with Carvacrol Nanoparticles for Bone Tissue Engineering |
| Author(s) |
Aditi Dahiya, Susmita Bose |
| On-Site Speaker (Planned) |
Aditi Dahiya |
| Abstract Scope |
Carvacrol, found in oregano, has therapeutic potential to treat bone defects, but its application is limited by its poor solubility and stability. We hypothesize, encapsulating it in nanoparticles could potentially overcome this issue. This study aims to improve the solubility and stability of carvacrol by encapsulating it in lipid nanoparticles and incorporating it into a 3D-printed silica-doped scaffold to treat patient-specific disorders. Silica has been reported to enhance the biological properties of calcium phosphate, making it a valuable addition to the scaffold. It was found that nanoparticles enhanced the release of carvacrol on the silica-doped scaffold by 55% after 35 days. It also inhibited bacterial viability by ~97%, and the human osteosarcoma cell viability was reduced by ~70% compared to the control. The results indicate that Carvacrol nanoparticles effectively aid bone tissue engineering. |