About this Abstract |
Meeting |
MS&T23: Materials Science & Technology
|
Symposium
|
3D Printing of Biomaterials and Devices
|
Presentation Title |
C-6: Synergistic Effects of Carvacrol and Curcumin Nanoparticle on 3D Printed Scaffold for Bone Tissue Engineering |
Author(s) |
Aditi Dahiya, Susmita Bose |
On-Site Speaker (Planned) |
Aditi Dahiya |
Abstract Scope |
Carvacrol and curcumin are two phytochemical compounds known for their anti-inflammatory, anticancer, and antibacterial properties. Although carvacrol and curcumin have been extensively studied individually, their synergistic effects remain unexplored for bone tissue engineering. This study investigates the combined effects of carvacrol and curcumin through nanoparticle encapsulation. To assess the potential of these compounds in bone tissue engineering, the dual drug nanoparticles were loaded onto 3D-printed calcium phosphate scaffolds. Nanoparticle encapsulated drugs exhibit controlled release from the 3D printed substrates with ~45% and ~55% release of carvacrol and curcumin, respectively for 7 days at physiological pH. The nanoparticle-treated scaffold promoted osteoblast cell activity and inhibited bacterial and osteosarcoma cell growth. The results indicate that the development of functionalized 3D-printed scaffolds for bone tissue engineering can be used in treating patient-specific bone-related diseases. |