| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
3D Printing of Biomaterials and Devices
|
| Presentation Title |
Effect of Release of Garlic Extract from CaP Bone Grafts for Bone Tissue Engineering Applications |
| Author(s) |
Priya Kushram, Susmita Bose |
| On-Site Speaker (Planned) |
Priya Kushram |
| Abstract Scope |
Bone diseases such as osteoporosis lead to the formation of critical-size bone defects which does not heal on their own. Calcium phosphate (CaP) bone graft material has been an excellent choice to treat these defects due to its compositional similarity with bone, excellent biocompatibility, and osteoconductivity. Extract from garlic, such as allicin, has also been known for its therapeutic behavior towards the bone. This work aims to fabricate garlic extract-loaded CaP bone grafts and understand their effect on the activity of osteoclast and osteoblast cells. The controlled release of garlic extract induces a 52 % reduction in osteoclast activity compared with the untreated substrate. Further, it shows an increase in the expression of alkaline phosphatase with garlic extract, indicating the formation of bone. The results indicate that multifunctional CaP bone grafts loaded with garlic extract could be a promising strategy for promoting bone formation for various orthopedic and dental applications. |