About this Abstract |
Meeting |
2024 TMS Annual Meeting & Exhibition
|
Symposium
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Mechanical Behavior at the Nanoscale VII
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Presentation Title |
The Effect of Nanomechanical Behavior on the Manufacturing of Pharmaceutical Tablets |
Author(s) |
Sushmita Majumder, Tianyi Xiang, Vikram Chandrashekhar Joshi, Calvin Sun, Nathan Mara |
On-Site Speaker (Planned) |
Sushmita Majumder |
Abstract Scope |
Successful compaction of pharmaceutical powders into tablets requires an understanding of the mechanical properties at the molecular level. The crystal structure and habit, along with its facet-dependent Young's modulus, indentation hardness, and fracture toughness are expected to dictate the compactibility and overall robustness of the tablets. However, little is known about the mechanical property correlation between nanoindentation and powder compaction. This work aims to characterize the mechanical properties of molecular crystals using an advanced method of nanoindentation and relate those to their compacted tablets formed. For succinic acid, we observed that the preferred orientations of the crystal planes at different compaction forces are (011), (111) and (121) on the well-compacted tablets. Moreover, the nanoindentation results are consistent with that of the single crystal property values. Thus, the molecular crystal geometry, orientation of the crystal planes in the tablets, and their mechanical properties have the potential to predict the tableting performance. |
Proceedings Inclusion? |
Planned: |
Keywords |
Mechanical Properties, Other, |