| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials for Biomedical Implants
|
| Presentation Title |
H-1: Bioactive Glass-ceramic Nanoparticle for Medical Implants |
| Author(s) |
Sun H. Latt, Pedram Sotoudeh Bagha, Andres Larraza, Mehdi Razavi |
| On-Site Speaker (Planned) |
Sun H. Latt |
| Abstract Scope |
One obstacle in development of a bioresorbable magnesium orthopedic implants is the rapid degradation rate of the magnesium implant. Therefore, the objective of this study was to synthesize and characterize a bioactive glass ceramic nanoparticle with diopside and monticellite phases for incorporation into magnesium implants to reduce the degradation rate and promote bone formation. The glass ceramic nanoparticle was successfully synthesized through a sol-gel synthesis method. X-ray diffraction confirmed diopside and monticellite phases, and tunnel electron microscopy imaging showed individual spherical particles 50-150 nm in size. In vivo interactions of the nanoparticles with cells involved in bone formation were characterized through biocompatibility assays. Our results showed that the biocompatibility of our nanoparticles to the tested cell types were dosage dependent. Additionally, human osteoclasts treated with the glass nanoparticle showed a reduction in TRAP expression. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Ceramics, Characterization |