| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials for Biomedical Implants
|
| Presentation Title |
Microstructural and Mechanical Analysis of Aerosol Jet 3D Printed Micropillars and Their Biocompatibility in Mouse Brain |
| Author(s) |
Sanjida Jahan, Chunshan Hu, Bin Yuan, Sandra Ritchie, Rahul Panat |
| On-Site Speaker (Planned) |
Sanjida Jahan |
| Abstract Scope |
Microelectrode arrays are used for recording electrophysiological activities from brain tissue which helps to understand neural activities and to diagnose and monitor neural diseases. Chronic recording from the same neuron over a period is possible with a biocompatible neural implant. Implantable neural probes with 3D gold electrodes have potential to record neural signals with minimum infection and inflammation to the brain tissue. To penetrate the brain tissue and record from it, 3D gold electrodes need to have mechanical strength and electrical reliability. In this work, we used Aerosol Jet nanoprinting to demonstrate the fabrication of gold micropillars with aspect ratios of up to 10:1 and studied for mechanical and microstructural characteristics. To evaluate their biocompatibility, 4×8 gold microelectrodes array with 250µm pitch were implanted in mouse brains up to 6weeks. Analysis of the brain slices showed minimal accumulation of astrocyte and microglia cell types between short-term and long-term observation periods. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Additive Manufacturing, Mechanical Properties |