| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials for Biomedical Implants
|
| Presentation Title |
Optimizing the Bio-degradability and Biocompatibility of a Biogenic Collagen Membrane Through Cross-linking And Zinc-doped Hydroxyapatite |
| Author(s) |
You Wu, Shouchen Chen, Zhuofan Chen |
| On-Site Speaker (Planned) |
You Wu |
| Abstract Scope |
Biogenic collagen membranes have been widely used as barriers in GBR and GTR. Nevertheless, their clinical performance remains unsatisfactory because of their low mechanical strength and fast degradation rate. As a fundamental nutritional trace element, zinc plays an active role in promoting the growth of cells and regulating the degradation of the collagen matrix. Herein, a biogenic collagen membrane was cross-linked with glutaraldehyde-alendronate to prolong its degradation time. The physiochemical and biological properties were enhanced by the incorporation of zinc-doped nanohydroxyapatite (nZnHA). Specifically, the cross-linking combined with 1% and 2% nZnHA seemed to endow the membrane with the most appropriate biocompatibility and tissue integration capability among the cross-linked membranes, as well as offering a degradation period of six weeks in a rat subcutaneous model. Thus, improving the clinical performance of biogenic collagen membranes by cross-linking together with the incorporation of nZnHA is a promising strategy for the improvement of biogenic collagen membranes. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Composites |