| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials for Biomedical Implants
|
| Presentation Title |
Bioinspired and Electrospun Helically Structured Nanofibers for Cardiac Patch Application |
| Author(s) |
Anamika Prasad, Alexi Switz |
| On-Site Speaker (Planned) |
Alexi Switz |
| Abstract Scope |
The electrospinning method is increasing in tissue engineering due to its ability to produce fibers in the nanometer to micrometer range. Such applications also demand greater control on fiber since fiber orientation dictates mechanical flexibility, strength, porosity and cellular response. However, most electrospinning setup provides limited ability to control fiber. Here we present the development of an in-house electrospinning setup capable of producing helically coiled fibrous mats, with is outcome evaluated as cardiac patches. Helically coiled structures were chosen for fiber design since such structures are common in nature in both the plant and animal worlds but have found limited application in tissue engineering. Polycaprolactone, an FDA-approved material was used for fiber formation. The function and biocompatibility of fibrous scaffolds was tested including its response to cardiomyocyte using a specially designed tissue setup. The outcome was compared with random fibrous mats to evaluate the effectiveness of helical coiling. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Mechanical Properties, Characterization |