| Abstract Scope |
Recent advances in biodegradable electronics enable wireless and controlled drug release platforms. This emerging technology for targeted pharmacologic treatment can be used in many local drug delivery applications, such as oncologic cases. Here, an on-demand controller operates an electrochemical reaction as crevice corrosion along the perimeter of metal gate. The inorganic metal gate, such as magnesium or molybdenum provides a new class of drug switch that doesn’t have leakage, while most polymer switch has leakage drug. In addition, the engineered reservoir can contain various solutions to release inside body, including proteins and hormones. Furthermore, multiple reservoirs and independent controllers enable cocktail therapies under controlled pharmacokinetics. All the constituent materials undergo complete bioresorption after drug treatment by eliminating the device load from the patient. Evaluations in cell cultures demonstrate the efficacy of this device for the treatment of cancer tissues by the release of the drug doxorubicin. Multiple and controlled releases in animal studies provide illustrations of blood glucose control by series delivery of insulin. |