| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
15th Symposium on Green and Sustainable Technologies for Materials Manufacturing and Processing
|
| Presentation Title |
Nanoclays in Biomaterials Design: From Regenerative Medicine to Invitro Disease Models |
| Author(s) |
Kalpana S. Katti, Dinesh R Katti, Sharad V Jaswandkar, Hanmant Gaikwad, Preetham Ravi, Quyen Hoang |
| On-Site Speaker (Planned) |
Kalpana S. Katti |
| Abstract Scope |
Our group introduced engineered nanoclays as bone biomaterials. Novel engineered nanoclays modified with amino acids are developed for fabrication of scaffolds for bone tissue engineering. Modification of nanoclay galleries with amino acids tailors mechanical properties and biological responses of the scaffolds on seeding with hMSCs. Nanoclays elicit favorable responses such as optimal differentiation of stem cells. We elucidate experimental studies on the role of nanoclays in stem cell differentiation and bone growth in addition to detailed molecular dynamics studies on the impact of clays on integrin activation. Integrins are important biomolecules responsible of adhesion of cells to substrates and have very significant role in cancer metastasis. Steered molecular dynamics studies on the cellular adhesion protein integrin interaction with the nanoclay provide an insight into stem cell differentiation. Nanoclay modifications and modifications of nanoclays provides a biologically favorable materials design in comparison to the issues of toxicity with many nanomaterials. |