About this Abstract |
Meeting |
MS&T21: Materials Science & Technology
|
Symposium
|
Next Generation Biomaterials
|
Presentation Title |
Metal Release from a Biomedical CoCrMo Alloy in Mixed Protein Solutions under Static and Sliding Conditions – Effects of Protein Aggregation and Metal Precipitation |
Author(s) |
Zheng Wei, Valentin Romanovski, Luimar Filho, Cecilia Cecilia, Yolanda Susanne Hedberg |
On-Site Speaker (Planned) |
Zheng Wei |
Abstract Scope |
Biomedical materials made of cobalt-chromium-molybdenum (CoCrMo) alloys are commonly used in artificial prostheses implants, which are exposed to friction and load. The release of Co, Cr, and Mo from these surfaces is governed by physical, chemical, and electrochemical processes. The extent of measured metal release from biomedical CoCrMo alloys into mixed protein solutions may be influenced by protein aggregation and metal precipitation effects. Metal release from a CoCrMo alloy was investigated in physiologically relevant solutions containing albumin and fibrinogen at physiological pH in static and sliding conditions for time periods between 1 and 24 hours. Proteins induced significant precipitation of metals and protein aggregates, which resulted in strongly underestimated released amounts of Co and Cr, but not Mo, especially under sliding conditions. Protein aggregates were found to precipitate on the surface of CoCrMo under static conditions. |