About this Abstract |
Meeting |
MS&T21: Materials Science & Technology
|
Symposium
|
Next Generation Biomaterials
|
Presentation Title |
Calcium Phosphate Nanoparticles as Intrinsic Inorganic
Antimicrobials |
Author(s) |
Vuk Uskokovic |
On-Site Speaker (Planned) |
Vuk Uskokovic |
Abstract Scope |
Pathogenic and opportunistic bacteria rapidly develop resistance to antibiotics and it is likely that the next pandemic after COVID-19 will be bacterial. Inorganic nanoparticles offer one, albeit insufficiently explored, avenue for developing alternatives to the shortcomings of traditional, small-molecule antibiotics. Calcium phosphate (CP) nanoparticles belong to the new wave of abundant and naturally accessible nanomaterials applicable as a means to various technological ends. Here I will present findings of a comprehensive study on the intrinsic antibacterial effect exhibited by two distinct CP phases: an amorphous CP (ACP) and hydroxyapatite (HAp). In addition to these efficacy studies, results of studies aimed at elucidating the mechanism of action of CP nanoparticles will be presented. These findings present grounds for the optimization of CP nanoparticle properties for activity against regular and resistant bacterial strains comparable to that of Ag. |