About this Abstract |
Meeting |
MS&T21: Materials Science & Technology
|
Symposium
|
Next Generation Biomaterials
|
Presentation Title |
Hierarchical Hybrid Carbon Nanotube Enhanced Bioscaffolds for Wound Healing |
Author(s) |
Soham Parikh, Wenhu Wang, Tyler Nelson, Courtney Sulentic, Sharmila Mukhopadhyay |
On-Site Speaker (Planned) |
Soham Parikh |
Abstract Scope |
Injuries involving skin cause a significant socioeconomic burden. In 2018 alone, such injuries required more than $28 billion for Medicare. Current wound healing scaffolds are limited in sterilization options, storage, and cell proliferation. In this study, we have investigated keratinocyte cell growth on Carbon Nanotube (CNT) enriched biocompatible carbon fabric as potential wound healing scaffolds. It was seen that these materials provide excellent biocompatibility for keratinocytes as shown by cytotoxicity, cell proliferation, and cell migration analyses. They also provide cytoprotection against environmental stressors such as Ultraviolet-B rays. One focus of this study was to understand if and how modification of these surfaces can be used to influence cell health and proliferation. Results show that cell proliferation mechanisms are impacted by functionalization that alters the CNT carpet length and the hydrophilic/hydrophobic behavior of nanotubes. These proof-of-concept studies indicate the strong future promise of adapting these bio-mimetic scaffolds for tissue engineering applications. |