About this Abstract |
Meeting |
MS&T21: Materials Science & Technology
|
Symposium
|
Next Generation Biomaterials
|
Presentation Title |
Sustained Delivery of Anticancer and Antimicrobial Drugs through Hollow Silica Capsules as Transporters |
Author(s) |
Eva Krakor, Isabel Gessner, Sanjay Mathur |
On-Site Speaker (Planned) |
Sanjay Mathur |
Abstract Scope |
Hollow mesoporous silica particles (HMSC) have aroused tremendous interest in the field of drug delivery due to their unique properties like high biocompatibility, large surface areas and high loading capacities due to a protected hollow core. HMSC were synthesized using an iron oxide template which was coated with silica through sol-gel synthesis followed by the removal through acidic leaching. The porosity was analyzed using nitrogen adsorption-desorption method revealing a pore size of circa 4 nm. Cytotoxicity was determined using cell viability test towards HEK293 cells, demonstrating that no reduction of cell viability was observed even at high concentrations (100 µg/ml). Their capability as drug delivery vehicle was tested, by loading a hydrophilic antibiotic and a hydrophobic anticancer compound and a pH dependent release at was monitored via UV-Vis spectroscopy. Antibiotic-loaded HMSC also revealed a complete growth inhibition of E.coli over 18 hours, demonstrating their promising potential as drug delivery vehicle. |