Abstract Scope |
Hydroxyapatite/collagen bone-like nanocomposite, HAp/Col, is a bone void filler which is substituted with new bone by bone remodeling process. To ignore implant associated infection, antimicrobial activity for first 5 days is important to reduce the risk of infection. In the present study, we focus on silver nanoparticles (SNPs) as antimicrobial agent to prepare the HAp/Col having wide-spectrum antimicrobial activity and lower risk to form drug resistant microorganisms. Silver nanoparticles adsorbed on the HAp/Col powder (HCP) up to 1492 mg/g<sub>HCP</sub> in 48 h at SNP concentration of 143 g/g<sub>HCP</sub> and desorbed approximately 6 % of adsorbed SNPs in 1 days. According to antibacterial tests for <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, the adsorbed and desorbed amounts were sufficient. Further, cytotoxicity dosage of the present SNPs was higher than lowest efficient antibacterial amounts. These results demonstrated that the SNP-loaded HAp/Col is a good candidate for an antibacterial bone void filler material. |