| About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Enhancing In Vitro Efficacy of Irinotecan in Colorectal Cancer Cells through Polymeric Chitosan Nanoparticle Delivery |
| Author(s) |
Dilip Reddy Gunturu, Amol Morrow, Lauryn Duhart, Temesgen Samuel |
| On-Site Speaker (Planned) |
Dilip Reddy Gunturu |
| Abstract Scope |
Colorectal cancer is a prevalent global health concern, with irinotecan serving as a clinical treatment option. However, its efficacy is hindered by adverse effects. We investigate chitosan nanoparticles as carriers for irinotecan delivery to enhance therapeutic outcomes. Leveraging chitosan's biodegradability and enhanced drug bioavailability, we synthesized irinotecan-loaded polymeric nanoparticles via ionic gelation. Characterization included size, shape, and loading efficiency assessment, followed by cytotoxicity and cell cycle modulation evaluation on colorectal cancer cells. Chitosan-encapsulated irinotecan nanoparticles exhibited superior efficacy in reducing cell viability compared to conventional delivery methods. Moreover, they induced significant alterations in cell cycle progression, suggesting potential mechanisms of action. These results highlight chitosan nanoparticles as promising tools for enhancing irinotecan delivery and efficacy in colorectal cancer therapy, paving the way for advanced biomaterial-based cancer treatments. Further investigations into their mechanism and in vivo efficacy are warranted for their clinical translation. |