| About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Nanocarriers for Stimuli-Responsive Drug Delivery and Tumor Specific Localization |
| Author(s) |
Shaista Ilyas, Annika Szymura, Sumiya Iqbal, Felix M. Mottaghy, Sanjay Mathur |
| On-Site Speaker (Planned) |
Sanjay Mathur |
| Abstract Scope |
Low solubility of the molecular drugs fetches poor efficacy and systemic toxicity. Transporting and/or encapsulating the drug molecules via nanocarriers promise long blood circulation time. Fusion of molecules on the surface of nanocarriers facilitate overcoming intrinsic physiological barriers of clearance through innate immune system and ensure safe delivery of therapeutics to tumor. In our research we have develop numerous type of mesoporous hollow capsules/ and nanofibres for the encapsulation of molecular drug inhibitors and radionuclides beside complementary functionalities through covalent rooted strategies. Stimuli-responsive sealing based on hydrophilic polymers, natural molecules or lipid on carrier surface assisted enhanced drug storage and controlled release. These nanocarriers demonstrated an outstanding therapeutics response and specificity to breast cancer and the hard to handle TNBC. Our data showed that that nanocarriers possess potential for stimuli-responsive delivery of drugs and radiations (68Ga and 177Lu) to the site. |