| About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
C-3: Chitosan/Bioactive Glass Printed Scaffold for Peripheral Nerve Regeneration |
| Author(s) |
Larissa Ribeiro Lourenco, Roger Borges, Mônica Mathor, Carlos Silva, Juliana Marchi |
| On-Site Speaker (Planned) |
Larissa Ribeiro Lourenco |
| Abstract Scope |
Peripheral nerve injuries impact patients' quality of life through sensory and motor capacity loss. The regeneration treatment is difficult and generally reaches only a 50% functional recovery rate, still being a challenge in this field. Biomaterials can be successfully applied as scaffolds to improve peripheral nerve regeneration in the context of tissue engineering. In this work, a chitosan hydrogel containing different amounts of bioactive glass (BG) was developed aiming at the 3D printing of neural scaffolds. After printing, the properties of the materials were analyzed through microstructure, mechanical, and biological assays using PC12 cells. BG addition enhanced the shape fidelity of the material during the printing process. The mechanical properties of the scaffolds with lower BG concentrations improved, and the materials showed high cell viability. Overall, precise and reproducible scaffolds were developed with suitable mechanical properties promising for nerve regeneration applications. |