| About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Novel Nano-Oxide Surfaces for Drug Resistant Pathogen Mitigation |
| Author(s) |
Deepa Shah, Craig J. Neal, Sudipta Seal, William Self |
| On-Site Speaker (Planned) |
William Self |
| Abstract Scope |
Over several decades, a great deal of attention is paid to drug development for antiviral/ antibacterials, but drug resistant pathogen mitigation is still a challenge. This talk will discuss an example of a unique nanomaterial to mitigate nosocomial pathogen Clostridioides difficile, which colonizes the gut causing diarrhea and inflammation. C. difficile spores can survive for months on contaminated surfaces. Common disinfecting agents such as bleach and peroxides are used to prevent this, but they pose serious health concerns. Here we developed a redox-active, silver-modified cerium oxide nanoparticles (AgCNP) formulations as a safer alternative. In vitro studies with AgCNP under different experimental conditions revealed a bactericidal effect against C. difficile with sporicidal activity evidenced as a 4-log reduction in germinating spores. The talk will include discussion of nanomaterial surface-biomolecule interactions as they relate to spore germination, particle surface fouling, and bactericidal/static mechanisms towards C. difficile. |