| Abstract Scope |
Bone tissue engineering (BTE) is dominated by scaffold-based tissue engineering strategies, and developing BTE scaffolds traditionally uses the design-fabrication-assessment-design loop which involves laborious work and is time-consuming. Performing computational simulation analysis for scaffolds achieved by computer-aided design and produced by additive manufacture technologies can significantly accelerate scaffold development. Furthermore, biomimetic BTE scaffolds are desirable for enhancing bone tissue regeneration. In this study, the structure of human cancellous bone, which was obtained from open-source data, was reconstructed to generate the porous structure for biomimetic BTE scaffolds. Subsequently, finite element analysis software ANSYS 2023 R1 was used to simulate compressive deformation of these cancellous bone structure-based scaffolds under different applied loads. Poly(lactic acid) (PLA) was used as the scaffold material, and hence biomimetic PLA scaffolds were studied for their mechanical behavior through computational simulation. This study shows the valuable contributions of computer-aided design and evaluation for developing new BTE scaffolds. |