| About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Processing of Drugs with Poor Water Solubility for Microneedle Drug Delivery |
| Author(s) |
Andrew Sachan, Roger Jagdish Narayan |
| On-Site Speaker (Planned) |
Roger Jagdish Narayan |
| Abstract Scope |
One of the biggest obstacles in pharmaceutical sciences is finding efficient ways to deliver drugs with low water solubility. We consider two potential methods for administering drugs that have low water solubility: (a) utilizing piezoelectric inkjet printing to deposit the drug onto the surface of microneedles within a microneedle array, and (b) employing matrix assisted pulsed laser evaporation to deposit the drug onto the surface of microneedles within a microneedle array. We tested piezoelectric inkjet printing for depositing voriconazole, an antifungal with low water solubility, on solid polyglycolic acid microneedles. In a separate study, a technique known as matrix assisted pulsed laser evaporation was utilized to effectively deposit the antifungal and antiparasitic agent known as amphotericin B onto the surface of sturdy polyglycolic acid microneedles. The structure and in vitro biological properties of microneedles coated with piezoelectric inkjet printing and matrix assisted pulsed laser evaporation will be described. |