About this Abstract |
Meeting |
2022 Annual International Solid Freeform Fabrication Symposium (SFF Symp 2022)
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Symposium
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2022 Annual International Solid Freeform Fabrication Symposium (SFF Symp 2022)
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Presentation Title |
3D Printed Bioactive Glass-Hydrogel Scaffolds for Craniofacial Bone Defects |
Author(s) |
Fateme Fayyazbakhsh, Nathan W. S. Hirsch, Yue-Wern Huang, Delbert Day, Ming C. Leu |
On-Site Speaker (Planned) |
Ming C. Leu |
Abstract Scope |
Gelatin/alginate-based hydrogels are widely used as tissue engineering matrices for bone regeneration. Recent studies employed inorganic phases to enhance mechanical strength by mimicking the normal bone’s biphasic structure. In this study, we examined the tunable functionality of 3D printed scaffolds using gelatin, alginate, and bioactive glass in terms of mechanical properties, biodegradation, and bioactivity for craniofacial defects. To evaluate printability, the rheological behavior and shape fidelity of the 3D printed scaffolds were analyzed and related to the scaffold composition. The results demonstrated that alginate has a positive effect on flowability, shape fidelity, and mechanical strength by forming crosslinks between the hydrogel network and ions released from glass. Biological tests showed the 3D printed scaffolds with higher gelatin content had higher cell viability and proliferation. The results from this research showed that the 3D printed bioactive glass-hydrogel scaffolds are promising candidates for craniofacial bone regeneration with tunable biodegradation and mechanical properties. |
Proceedings Inclusion? |
Definite: Post-meeting proceedings |