About this Abstract |
Meeting |
6th International Congress on 3D Materials Science (3DMS 2022)
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Symposium
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6th International Congress on 3D Materials Science (3DMS 2022)
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Presentation Title |
3D Characterization of Inhalation Drug Formulations Using X-ray Microscopy
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Author(s) |
Hrishi Bale, Parmesh Gajjar, Benjamin Tordoff, Philip Withers, Darragh Murnane |
On-Site Speaker (Planned) |
Hrishi Bale |
Abstract Scope |
Drug delivery to the lungs is a highly desirable but extremely challenging field in pharmaceutical sciences. The challenge is to engineer a drug formulation that can reach the deep lungs and can be easily aerosolized and administered when required. Understanding the microstructure of powder formulations is crucial, yet current characterization methods give incomplete information. Conventional techniques like Laser-Diffraction(LD) and Optical-Microscopy(OM) are limited due to the assumption of sphericity and can give variable results depending on particle orientation and dispersion. Furthermore, the challenges of characterizing the formulations are immensely elevated when applied to blends of active pharmaceutical ingredients(API’s) and carrier particles due to their similar density and particle sizes.
We present results from a new powder analytical technique using 3D X-ray microscopy applied to characterize pure a-Lactose monohydrate powders with different characteristics. We will also demonstrate results from a new 3D particle classification workflow that accurately classifies particles in a blend. |
Proceedings Inclusion? |
Definite: Other |