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Meeting 2020 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title Application of Titanium Dioxide Nanotubes and Lattice Light-sheet Microscopy in Establishing Early-stage Cellular Response Mechanisms
Author(s) Jevin G. Meyerink, Scott Wood, Jeremy Mercuri, Robert Anderson, Brandon Scott, Grant Crawford
On-Site Speaker (Planned) Jevin G. Meyerink
Abstract Scope There is a need for novel titanium surface treatments, like TiO2 nanotubes, to promote osteogenesis on orthopedic implants, yet, the exact mechanisms by which this nanostructure influences adhesion dynamics and how those dynamics subsequently mediate intracellular signaling pathways to dictate cell function, remains unclear. The purpose of this study is to use advanced live-cell imaging techniques to understand how nanostructured surfaces influence early-stage cell adhesion. We investigate the influence of TiO2 nanotube structure on initial cell-TiO2 nanotube interaction of various cell types (pre-osteoblasts, macrophages, mesenchymal stem cells) via lattice light sheet microscopy (LLSM). Taking advantage of recent advances in LLSM, we are capable of rapid volumetric image acquisition during early-stage adhesion and long imaging duration (hours to days). In addition, we evaluate the requirement for specific proteins in the nanotube diameter-modulation of osteogenic and phagocytic signaling dynamics, with the goal of correlating these important dynamic processes to TiO2 nanotube diameter.
Proceedings Inclusion? Planned: Publication Outside of TMS


Advances in Printing of Polymers at Small Length Scales
AMP-loaded Mesoporous Strontium Silicates with Improved Bioactivity and Antibacterial Capability
Application of Titanium Dioxide Nanotubes and Lattice Light-sheet Microscopy in Establishing Early-stage Cellular Response Mechanisms
Attachment Surface Energy as an Indicator for Adhesion of Nitrifying Bacteria
B-26: Fabrication of Nanogenerator and Its Potential Application in Implantable Biomedical Devices
Bioinspired Mineralization of Natural Polymers for Biomedical Applications
Biological Crystallization of Ultrahard Teeth and Translation to Multi-functional Materials
Biological Fate of Engineered Nanomaterials: Tracing Aggregation/degradation and Nanomaterial Dose In-vitro and In-vivo
Cancer Cell Mechanics: The Role of Actin
Chiral Inorganic Nanostructures
Enabling Manufacturing at the Bio-Nano Interface using Gyratory Forming
Enzymes Grafted on Electrodes for Biofuel Cells: Lessons from Multiscale Modeling Approaches
Functional Nanomaterials and Their Applications in the Therapy of Cancer and Infectious Diseases
Inkjet Printed Nano-patterned Aptamer-based Sensors for Improved Optical Detection of Foodborne Pathogens
Molecular Mechanisms in Metal Oxide Nanoparticle Interactions with Biomolecules
Molecular Recognition and Assembly of Biomaterials: Computational and Data Science Tools for Property Predictions
Monitoring Interaction of Nanomaterials with Biomolecules and Their Dosimetry at Single Cell Level
Nano-engineered DNA based Hydrogel as a New Injectable Drug Delivery Platform
Peptides as Modulators of Materials Properties: Case Study MOFS and Composites based on ZnO
The Internal Nano-interfaces of Spider Silk: Finding the Molecular-scale Origins of its Strength

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