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Meeting 2020 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title AMP-loaded Mesoporous Strontium Silicates with Improved Bioactivity and Antibacterial Capability
Author(s) Isha Mutreja, Kami Hogan, Dhiraj Kumar, Conrado Aparicio
On-Site Speaker (Planned) Isha Mutreja
Abstract Scope We synthesized multifunctional mesoporous silicate nanostructures (MSNs): Ca-MSN, Sr-doped CaMSNs (Sr-CaMSNs) and novel Sr-MSNs via sol-gel method for bone regeneration and as antimicrobial peptide (AMP) cargo delivery nano-system. MSNs were characterized for cytotoxicity against mesenchymal stem cells as well as chemically and structurally using scanning electron miscroscopy with energy dispersive X-ray spectroscopy and wide-angle x-ray diffractometry. Peptide loading and release from MSNs was assessed using the fluorescent-labelled GL13K AMP. Ca-MSNs and Sr-CaMSNs were 20050nm in diameter, and Sr-MSNs were 40050nm. All MSNs had the expected composition, were amorphous, and had similar peptide-loading efficiency (96 1%) with slow release profile. Sr-MSNs and Ca-MSNs released 7% and 4% of loaded AMP in 72h, respectively. MSNs improved cell metabolic activity, which confirmed their good cytocompatibility. In conclusion, Sr-MSNs support cell growth over extended periods and prolonged AMP release showing potential application for bone regeneration with antimicrobial potency.
Proceedings Inclusion? Planned: Publication Outside of TMS

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

Advances in Printing of Polymers at Small Length Scales
AMP-loaded Mesoporous Strontium Silicates with Improved Bioactivity and Antibacterial Capability
Application of Titanium Dioxide Nanotubes and Lattice Light-sheet Microscopy in Establishing Early-stage Cellular Response Mechanisms
Attachment Surface Energy as an Indicator for Adhesion of Nitrifying Bacteria
B-26: Fabrication of Nanogenerator and Its Potential Application in Implantable Biomedical Devices
Bioinspired Mineralization of Natural Polymers for Biomedical Applications
Biological Crystallization of Ultrahard Teeth and Translation to Multi-functional Materials
Biological Fate of Engineered Nanomaterials: Tracing Aggregation/degradation and Nanomaterial Dose In-vitro and In-vivo
Cancer Cell Mechanics: The Role of Actin
Chiral Inorganic Nanostructures
Enabling Manufacturing at the Bio-Nano Interface using Gyratory Forming
Enzymes Grafted on Electrodes for Biofuel Cells: Lessons from Multiscale Modeling Approaches
Functional Nanomaterials and Their Applications in the Therapy of Cancer and Infectious Diseases
Inkjet Printed Nano-patterned Aptamer-based Sensors for Improved Optical Detection of Foodborne Pathogens
Molecular Mechanisms in Metal Oxide Nanoparticle Interactions with Biomolecules
Molecular Recognition and Assembly of Biomaterials: Computational and Data Science Tools for Property Predictions
Monitoring Interaction of Nanomaterials with Biomolecules and Their Dosimetry at Single Cell Level
Nano-engineered DNA based Hydrogel as a New Injectable Drug Delivery Platform
Peptides as Modulators of Materials Properties: Case Study MOFS and Composites based on ZnO
The Internal Nano-interfaces of Spider Silk: Finding the Molecular-scale Origins of its Strength

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