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Meeting 2020 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title Functional Nanomaterials and Their Applications in the Therapy of Cancer and Infectious Diseases
Author(s) Hanene Belkahlac, Rym Boudjemaab, John S. Lomas, Olivier Micheauc, Claire Wilhelm, Hyacinthe Randriamahazaka, Miryana Paris Hemadi
On-Site Speaker (Planned) Miryana Paris Hemadi
Abstract Scope Multifunctional nanomaterials are finding applications in nanomedicine. In particular, magnetic and Carbon nanomaterials are extensively used in theranostics especially for imaging and treatment by thermal therapy. Firstly, bioimaging and photothermia(PT) were performed on E. coli, a Gram(-) bacterium, incubated with Carbon Dots(CDs). Remarkably, by PT, CDs are able to eradicate bacteria in their exponential and stationary phases. Images obtained by 3D super-resolution fluorescence microscopy clearly show the CD distributions in surviving bacteria after mild photothermal treatment. Secondly, In order to optimize the therapeutic efficacy and to enhance the targeting abilities in a cell cancer line, iron oxide nanoclusters were functionalized by different proteins: TRAIL, Transferrin and HSA. The efficiency was compared with magnetic hyperthermia or PT. An original mechanism was established that implies hotspot generation around the nanoclusters and, therefore, at the cell surface in the vicinity of the targeted-receptors, leading to disruption of the membrane and subsequent cell death.
Proceedings Inclusion? Planned: Publication Outside of TMS


Advances in Printing of Polymers at Small Length Scales
AMP-loaded Mesoporous Strontium Silicates with Improved Bioactivity and Antibacterial Capability
Application of Titanium Dioxide Nanotubes and Lattice Light-sheet Microscopy in Establishing Early-stage Cellular Response Mechanisms
Attachment Surface Energy as an Indicator for Adhesion of Nitrifying Bacteria
B-26: Fabrication of Nanogenerator and Its Potential Application in Implantable Biomedical Devices
Bioinspired Mineralization of Natural Polymers for Biomedical Applications
Biological Crystallization of Ultrahard Teeth and Translation to Multi-functional Materials
Biological Fate of Engineered Nanomaterials: Tracing Aggregation/degradation and Nanomaterial Dose In-vitro and In-vivo
Cancer Cell Mechanics: The Role of Actin
Chiral Inorganic Nanostructures
Enabling Manufacturing at the Bio-Nano Interface using Gyratory Forming
Enzymes Grafted on Electrodes for Biofuel Cells: Lessons from Multiscale Modeling Approaches
Functional Nanomaterials and Their Applications in the Therapy of Cancer and Infectious Diseases
Inkjet Printed Nano-patterned Aptamer-based Sensors for Improved Optical Detection of Foodborne Pathogens
Molecular Mechanisms in Metal Oxide Nanoparticle Interactions with Biomolecules
Molecular Recognition and Assembly of Biomaterials: Computational and Data Science Tools for Property Predictions
Monitoring Interaction of Nanomaterials with Biomolecules and Their Dosimetry at Single Cell Level
Nano-engineered DNA based Hydrogel as a New Injectable Drug Delivery Platform
Peptides as Modulators of Materials Properties: Case Study MOFS and Composites based on ZnO
The Internal Nano-interfaces of Spider Silk: Finding the Molecular-scale Origins of its Strength

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