| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Functional Nanomaterials and Their Applications in the Therapy of Cancer and Infectious Diseases |
| Author(s) |
Hanene Belkahlac, Rym Boudjemaab, John S. Lomas, Olivier Micheauc, Claire Wilhelm, Hyacinthe Randriamahazaka, Miryana Paris Hemadi |
| On-Site Speaker (Planned) |
Miryana Paris Hemadi |
| Abstract Scope |
Multifunctional nanomaterials are finding applications in nanomedicine. In particular, magnetic and Carbon nanomaterials are extensively used in theranostics especially for imaging and treatment by thermal therapy. Firstly, bioimaging and photothermia(PT) were performed on E. coli, a Gram(-) bacterium, incubated with Carbon Dots(CDs). Remarkably, by PT, CDs are able to eradicate bacteria in their exponential and stationary phases. Images obtained by 3D super-resolution fluorescence microscopy clearly show the CD distributions in surviving bacteria after mild photothermal treatment. Secondly, In order to optimize the therapeutic efficacy and to enhance the targeting abilities in a cell cancer line, iron oxide nanoclusters were functionalized by different proteins: TRAIL, Transferrin and HSA. The efficiency was compared with magnetic hyperthermia or PT. An original mechanism was established that implies hotspot generation around the nanoclusters and, therefore, at the cell surface in the vicinity of the targeted-receptors, leading to disruption of the membrane and subsequent cell death. |
| Proceedings Inclusion? |
Planned: Publication Outside of TMS |