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Meeting 2020 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title Bioinspired Mineralization of Natural Polymers for Biomedical Applications
Author(s) Conrado Aparicio
On-Site Speaker (Planned) Conrado Aparicio
Abstract Scope We use natural organic matrices as structural templates for bottom-up fabrication of hybrid nanocomposites to build advanced biomaterials for tissue engineering. By controlling mineral deposition in the organic matrices, predictable morphology of the mineralized nanocomposites can be obtained. We have designed and used elastin-like recombinamers (ELRs) and different forms of nanocellulose to template mineralization of hydroxyapatite nanocrystals using biomimetic processes. The minerals are deposited within the framework/fibril of the polymeric template, attaining high mineral density, bioactive response, and mechanical properties similar to those of natural hard tissues. ELRs are recombinant polypeptides that can self-assemble into twisted filaments. Cellulose nanofibers can be aligned so that intrafibrillar nanocompartments can be achieved. Amorphous mineral precursors infiltrate into the nanocompartments between the polymer’s ordered structures and then coalesce and crystallize. Diverse hybrid nanocomposites with optimized mechanical and biological properties can be constructed, suited for the treatment of hard tissue defects using regenerative medicine approaches.
Proceedings Inclusion? Planned: Publication Outside of TMS


Advances in Printing of Polymers at Small Length Scales
AMP-loaded Mesoporous Strontium Silicates with Improved Bioactivity and Antibacterial Capability
Application of Titanium Dioxide Nanotubes and Lattice Light-sheet Microscopy in Establishing Early-stage Cellular Response Mechanisms
Attachment Surface Energy as an Indicator for Adhesion of Nitrifying Bacteria
B-26: Fabrication of Nanogenerator and Its Potential Application in Implantable Biomedical Devices
Bioinspired Mineralization of Natural Polymers for Biomedical Applications
Biological Crystallization of Ultrahard Teeth and Translation to Multi-functional Materials
Biological Fate of Engineered Nanomaterials: Tracing Aggregation/degradation and Nanomaterial Dose In-vitro and In-vivo
Cancer Cell Mechanics: The Role of Actin
Chiral Inorganic Nanostructures
Enabling Manufacturing at the Bio-Nano Interface using Gyratory Forming
Enzymes Grafted on Electrodes for Biofuel Cells: Lessons from Multiscale Modeling Approaches
Functional Nanomaterials and Their Applications in the Therapy of Cancer and Infectious Diseases
Inkjet Printed Nano-patterned Aptamer-based Sensors for Improved Optical Detection of Foodborne Pathogens
Molecular Mechanisms in Metal Oxide Nanoparticle Interactions with Biomolecules
Molecular Recognition and Assembly of Biomaterials: Computational and Data Science Tools for Property Predictions
Monitoring Interaction of Nanomaterials with Biomolecules and Their Dosimetry at Single Cell Level
Nano-engineered DNA based Hydrogel as a New Injectable Drug Delivery Platform
Peptides as Modulators of Materials Properties: Case Study MOFS and Composites based on ZnO
The Internal Nano-interfaces of Spider Silk: Finding the Molecular-scale Origins of its Strength

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