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Meeting 2020 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title Monitoring Interaction of Nanomaterials with Biomolecules and Their Dosimetry at Single Cell Level
Author(s) T. Venus, T. Meyer, J. Böttner, C. Merker, V, Calcagno, J. Keller, R. Landsiedel, D. Schwotzer, O. Creutzenberg, M. Moro, S. Moya, J. P. Longo, L. Muehlmann, Irina Estrela-Lopis
On-Site Speaker (Planned) Irina Estrela-Lopis
Abstract Scope The degree and the mechanism of uptake, localization and distribution of nanomaterials (NMs) in cells and organs are major issues concerning toxicity and risk assessment of the novel products. Furthermore, the application of NMs as devices for diagnostic and therapeutic purposes requires monitoring of their interaction with biomolecules. The translocation of NMs across plasma membranes, their quantification and interaction with metabolic relevant cellular elements and biomolecules were studied in in vitro as well in vivo by means of label-free imaging methods based on element and molecule analysis. A quantitative analysis of minor and trace elements on the surface of NMs within single cells were performed and correlated with the cellular adverse response. Furthermore monitoring NM uptake, their bioprocessing, interaction with biomolecules and induced biochemical changes as well diagnostic and prediction of adverse effects were studied in living cells by means of confocal Raman microspectroscopy, cluster analysis or principle component analysis.
Proceedings Inclusion? Planned: Publication Outside of TMS

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

Advances in Printing of Polymers at Small Length Scales
AMP-loaded Mesoporous Strontium Silicates with Improved Bioactivity and Antibacterial Capability
Application of Titanium Dioxide Nanotubes and Lattice Light-sheet Microscopy in Establishing Early-stage Cellular Response Mechanisms
Attachment Surface Energy as an Indicator for Adhesion of Nitrifying Bacteria
B-26: Fabrication of Nanogenerator and Its Potential Application in Implantable Biomedical Devices
Bioinspired Mineralization of Natural Polymers for Biomedical Applications
Biological Crystallization of Ultrahard Teeth and Translation to Multi-functional Materials
Biological Fate of Engineered Nanomaterials: Tracing Aggregation/degradation and Nanomaterial Dose In-vitro and In-vivo
Cancer Cell Mechanics: The Role of Actin
Chiral Inorganic Nanostructures
Enabling Manufacturing at the Bio-Nano Interface using Gyratory Forming
Enzymes Grafted on Electrodes for Biofuel Cells: Lessons from Multiscale Modeling Approaches
Functional Nanomaterials and Their Applications in the Therapy of Cancer and Infectious Diseases
Inkjet Printed Nano-patterned Aptamer-based Sensors for Improved Optical Detection of Foodborne Pathogens
Molecular Mechanisms in Metal Oxide Nanoparticle Interactions with Biomolecules
Molecular Recognition and Assembly of Biomaterials: Computational and Data Science Tools for Property Predictions
Monitoring Interaction of Nanomaterials with Biomolecules and Their Dosimetry at Single Cell Level
Nano-engineered DNA based Hydrogel as a New Injectable Drug Delivery Platform
Peptides as Modulators of Materials Properties: Case Study MOFS and Composites based on ZnO
The Internal Nano-interfaces of Spider Silk: Finding the Molecular-scale Origins of its Strength

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