| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Nano-engineered DNA based Hydrogel as a New Injectable Drug Delivery Platform |
| Author(s) |
Arghya Paul, Sayantani Basu, Settimio Pacelli |
| On-Site Speaker (Planned) |
Arghya Paul |
| Abstract Scope |
Injectable hydrogels present several advantages over pre-fabricated scaffolds including ease of delivery, shear thinning property and broad applicability in the fields of drug delivery and tissue engineering. Here we report development of a novel injectable hydrogel, composed of DNA and silicate nanodisks, as a drug delivery platform for orthoregeneration applications. Precisely, the hydrogel was designed by combining two different type of networks: a first network made of interconnections between neighboring DNA strands and a second one consisting of electrostatic interactions between the nanodisks and the DNA backbone. The silicate nanodisks were introduced to increase the viscosity of the DNA physical hydrogel and improve their shear-thinning properties. Additionally, the hydrogel network properties can be tailored to modulate the drug release kinetics, as per need. In vivo experimental results confirm that the hydrogel can efficiently deliver osteoinductive drugs and promote bone repair in rat model with critical size cranial bone defect. |
| Proceedings Inclusion? |
Planned: Publication Outside of TMS |