| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Biological Fate of Engineered Nanomaterials: Tracing Aggregation/degradation and Nanomaterial Dose In-vitro and In-vivo |
| Author(s) |
Sergio Moya |
| On-Site Speaker (Planned) |
Sergio Moya |
| Abstract Scope |
There is an urgent need for a deeper understanding of the impact of engineered nanomaterials (ENMs) on human health resulting from deliberate exposure to ENMs, such as in nanomedicine, or from accidental exposure. The physical characteristics of ENMs determine their interaction with biomolecules and the ENMs fate both intracellularly and at body level.
Several aspects of ENMs fate will be discussed in relation with ENM quantification and stability. Protein corona formation and stability, and the aggregation behavior ENMs will be investigated by means of Fluorescence Correlation Spectroscopy (FCS) in live cells along with ENMs trafficking. The bio distribution, organ accumulation and fate of radiolabelled ENMs will be studied in animal models by means of Positron Emission Tomography (PET). A dual radiolabelling strategy of core and coating will be presented using gamma emitters. Energy-discriminant Single-Photon Emission Computerised Tomography (SPECT) traces independently both labells and is used to evaluate NP integrity. |
| Proceedings Inclusion? |
Planned: Publication Outside of TMS |