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Meeting 2020 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title Cancer Cell Mechanics: The Role of Actin
Author(s) Dinesh Katti, Sharad Jaswandkar, H M Nasrullah Faisal, Kalpana S Katti
On-Site Speaker (Planned) Dinesh Katti
Abstract Scope The progression of cancer is manifested by extreme morphological and mechanical changes of the cancer cells as cells cluster and form tumors. The mechanobiology of cancer cells serves as a potential biomarker for cancer progression. We have constructed tissue-engineered test-beds to mimic the progression of prostate and breast cancer metastasized to the bone site and captured the evolution of cell morphology, cytoskeleton, and mechanics of the cells during cancer progression. Computational models of cancer cells demonstrate the crucial role of cytoskeletal elements such as actin and microtubules on cell mechanics. Actin dynamics during cancer progression is captured in the test-beds. A computational multiscale framework to evaluate the mechanical response of actin and actin conformations has been developed, allowing for molecular-scale interactions and changes to actin upscaled to a finite element model of cancer cells. The results elucidate the role of actin on the mechanobiology of cancer cells during progression.
Proceedings Inclusion? Planned: Publication Outside of TMS


Advances in Printing of Polymers at Small Length Scales
AMP-loaded Mesoporous Strontium Silicates with Improved Bioactivity and Antibacterial Capability
Application of Titanium Dioxide Nanotubes and Lattice Light-sheet Microscopy in Establishing Early-stage Cellular Response Mechanisms
Attachment Surface Energy as an Indicator for Adhesion of Nitrifying Bacteria
B-26: Fabrication of Nanogenerator and Its Potential Application in Implantable Biomedical Devices
Bioinspired Mineralization of Natural Polymers for Biomedical Applications
Biological Crystallization of Ultrahard Teeth and Translation to Multi-functional Materials
Biological Fate of Engineered Nanomaterials: Tracing Aggregation/degradation and Nanomaterial Dose In-vitro and In-vivo
Cancer Cell Mechanics: The Role of Actin
Chiral Inorganic Nanostructures
Enabling Manufacturing at the Bio-Nano Interface using Gyratory Forming
Enzymes Grafted on Electrodes for Biofuel Cells: Lessons from Multiscale Modeling Approaches
Functional Nanomaterials and Their Applications in the Therapy of Cancer and Infectious Diseases
Inkjet Printed Nano-patterned Aptamer-based Sensors for Improved Optical Detection of Foodborne Pathogens
Molecular Mechanisms in Metal Oxide Nanoparticle Interactions with Biomolecules
Molecular Recognition and Assembly of Biomaterials: Computational and Data Science Tools for Property Predictions
Monitoring Interaction of Nanomaterials with Biomolecules and Their Dosimetry at Single Cell Level
Nano-engineered DNA based Hydrogel as a New Injectable Drug Delivery Platform
Peptides as Modulators of Materials Properties: Case Study MOFS and Composites based on ZnO
The Internal Nano-interfaces of Spider Silk: Finding the Molecular-scale Origins of its Strength

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