|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||BioNano Interfaces and Engineering Applications
||Gingerol and EGCG Enhance Osteogenic and Antibacterial Properties of Ag-doped CaP Bone Grafts
||Yongdeok Jo, Susmita Bose
|On-Site Speaker (Planned)
As the world’s elderly population continues to grow rapidly, the number of orthopedic implant surgeries is increasing. During surgical intervention, the invasion of infectious agents frequently causes implant-related osteomyelitis. Antibiotics have been used to combat osteomyelitis in orthopedic applications. However, the high dose requirement, toxicity, and risk of treatment resistance have prompted interest in alternative multi-functionalized delivery systems with antibacterial and osteogenic properties. Silver (Ag) has provided antimicrobial properties to various microorganisms. E Epigallocatechin gallate (EGCG), the active compound in green tea leaves, and gingerol, a therapeutic compound extracted from ginger root, have shown the ability to enhance osteogenic properties and antibacterial properties. Our goal is to fabricate Ag-doped calcium phosphate (CaP) bone grafts with EGCG and gingerol to improve bone healing while providing infection prevention. Multifunctional Ag-doped CaP grafts with EGCG and gingerol have shown in vitro antibacterial properties to Staphylococcus aureus while enhancing in vitro osteoblast cellular activity.
||Biomaterials, Ceramics, Composites