|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||BioNano Interfaces and Engineering Applications
||Controlled Synthesis of Polystyrene/Citrate Capped AuNPs Microparticles for the Colorimetric Detection of Hg2+ Ions through Aptamer-target Interaction
||Ana Ulloa, Min Zhao, Qiyue Liang, George Chiu, Jan Allebach, Lia Stanciu
|On-Site Speaker (Planned)
Heavy metals toxicity has been proven to be a major public health concern. Among the heavy metals, mercury is considered the most toxic, but unfortunately, it is still widely distributed in the environment. Current detection methods for its monitoring include ICP-MS, HPLC, and ICL-AES and despite their high sensitivity and selectivity, they are still complex, required trained personnel, and are not suitable for On-Site detection. Therefore, the development of user-friendly and reliable sensors is necessary. This work puts forward a controlled synthesis process of aptamer-labeling Ps-AuNPs microparticles for the sensitive and quantifiable detection of Hg2+ ions (LOD= 1ppm) through colorimetric assays. The resulting paper-based microfluidic device (µ-PAD) as manufactured consists of a cost-effective, portable, and versatile aptasensor that serves as a basis for the fabrication of universal paper-based colorimetric platforms with the capability of multiplex and multi-replicates and it is promising for On-site applications in agriculture and environmental safety.
||Biomaterials, Surface Modification and Coatings, Thin Films and Interfaces