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Meeting 2022 TMS Annual Meeting & Exhibition
Symposium BioNano Interfaces and Engineering Applications
Presentation Title Grain Size Effects and Mechanisms for Increased Antimicrobial Efficiency in Ultrafine-grained Bulk Copper
Author(s) Evander Ramos, Isabella Bagdasarian, Yaqiong Li, Masuda Takahiro, Yoichi Takizawa, Justin Chartron, Alex Greaney, Zenji Horita, Joshua Morgan, Suveen N. Mathaudhu
On-Site Speaker (Planned) Suveen N. Mathaudhu
Abstract Scope Copper and it’s alloys have long been known for their antiviral and antibacterial properties, and in the course of the global pandemic, research on ways to accelerate their effectiveness have come to the forefront. Recent studies have reported that when the crystal size of bulk copper reduces towards the nanoscale, the anti-viral and anti-microbial efficiency increases non-linearly. The mechanisms for this are diverse, and include the increase in volume fraction of ionic pathways to the surface, oxidation-reduction, topological features and others. In this study, we investigate the antibacterial characteristics of nanocrystalline pure copper produced by severe plastic deformation (SPD), and based on a literature review and our own emerging data, attempt to unravel the mechanisms that promote bacteria or cell destruction as a function of grain size. The versatility of SPD methods allows for the fabrication of bulk components that, unlike thin-film coating approaches, may enable scalability of medical applications.
Proceedings Inclusion? Planned:
Keywords Nanotechnology, Copper / Nickel / Cobalt, Biomaterials

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

3D Printing for Bone Regeneration: Convergence of Knowledge
A New Approach to the Mechanics of DNA: Atoms-to-beam Homogenization
Alloy Design via 3D Printing for Metallic Implants
Antiviral Surface Topographies on Metal Surfaces
Bioinspired Interface for Titanium Implants
Bioinspired Wear-resistant Triboelectric Nanodevice for Biomechanical Energy Harvesting
Biomaterials by Design
Calcium Phosphate-based Bone Grafts with Curcumin and Vitamin C Shows Osteogenic, Chemo-preventive and Anti-bacterial Potential for Orthopaedic and Dental Applications
Computational Investigation of DNA-scaffolded Squariane Dye Aggregates
Computational Modeling of Cyanine Dyes Attached to DNA Scaffolds
Controlled Synthesis of Polystyrene/Citrate Capped AuNPs Microparticles for the Colorimetric Detection of Hg2+ Ions through Aptamer-target Interaction
Designing and Optimization of Bio-inspired 3D Structures — From Ordered TPMS to Disordered Reaction Models
Disrupted Osteogenesis at Bone Metastasis of Breast Cancer and Prostate Cancer
Gingerol and EGCG Enhance Osteogenic and Antibacterial Properties of Ag-doped CaP Bone Grafts
Grain Size Effects and Mechanisms for Increased Antimicrobial Efficiency in Ultrafine-grained Bulk Copper
Inductively Coupled Plasma for Cell and Microbial Interfacing Surfaces
K-14: AuNps Tailored Microneedle Based Point of Care Device Fabrication for Hormonal Sensing
K-15: Potentiometric Immunosensor for the Selective Thyroxine Detection Using Cu-MOF@PANI Composite in Serum Samples
Mechanics of Cellular Actin Filaments
Nanostructured Metals for Miniaturized Medical Implants with Improved Biofunctionality
NOW ON-DEMAND ONLY - Self-assembling Nanoclay Gels for Tissue Regeneration
Peptide-mediated Remineralizable Collagen Fibrils as a Model for Dentin Repair
Reverse Engineering Spider Silk by Disassembly and Assembly
Sensing of COVID-19 Antibodies and Antigens in Seconds via Aerosol Jet Nanoprinted Reduced Graphene Oxide Coated Three Dimensional Electrodes
Structural Development and Phase Transformation of Mesocrystalline Iron Oxides in the Ultrahard Teeth of Cryptochiton Stelleri
Zinc Functionalized Polydopamine-curcumin Coated 3D Printed Calcium Phosphate Scaffolds for Enhanced Osteogenesis, and in Vitro Chemoprevention
In vitro Pre-osteoblast Cell Differentiation by Luminescent Hydroxyapatite

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