|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||BioNano Interfaces and Engineering Applications
||Calcium Phosphate-based Bone Grafts with Curcumin and Vitamin C Shows Osteogenic, Chemo-preventive and Anti-bacterial Potential for Orthopaedic and Dental Applications
||Ujjayan Majumdar, Susmita Bose
|On-Site Speaker (Planned)
Repair of critical-sized tumor-resection defects caused by severe infection, ageing and tumor ablation still remains a significant challenge in clinical orthopedics. Calcium phosphate based materials are of cardinal importance in bone tissue engineering applications due to their resemblance with human hard tissues. The objective of the study is to understand the effects of controlled release of curcumin and Vitamin C co-delivery system on the osteogenic, chemo-preventive and antibacterial properties of Calcium phosphate scaffolds. The antibacterial potential of this co-delivery system was assessed against S. aureus and the obtained results indicate that fabricated compositions are ~ 80 % antibacterial compared to control sample. Initial osteogenic property characterization indicates higher cell viability on the curcumin – vitamin C loaded scaffolds. This presentation will discuss the controlled release kinetics of Curcumin and vitamin C co-delivery system and their osteogenic, chemo-preventive and anti-bacterial potential, suitable for tissue engineering applications.
||Ceramics, Biomaterials, Additive Manufacturing