| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
BioNano Interfaces and Engineering Applications
|
| Presentation Title |
Disrupted Osteogenesis at Bone Metastasis of Breast Cancer and Prostate Cancer |
| Author(s) |
Kalpana S. Katti, Haneesh Jasuja, Dinesh R Katti |
| On-Site Speaker (Planned) |
Kalpana S. Katti |
| Abstract Scope |
The WHO reports 3.4M incidences and 1M deaths due to breast and prostate cancer. Both breast and prostate cancer metastasize to bone. We use novel nanoclay-based tissue-engineered scaffolds to mimic the bone-niche. On seeding the bone-scaffold with commercial and patient-derived cell lines of breast and prostate cancer, we create humanoid testbeds of bone-metastasis. The bone-metastatic testbed is used to screen drugs and develop new metastasis biomarkers. We evaluate role of cancer cells on osteogenesis, which has significant ramifications on therapies for bone metastasis patients for whom skeletal failures are common. The bone regenerative process is well characterized with the role of the Wnt/β-catenin signaling pathway. We report that Wnt/β-catenin signaling governs osteogenesis within the cancer-proximity bone-microenvironment. Morphological changes as well as ultrastructural changes to collagen fibrils are observed at the proximity of cancer metastasis. The novel testbed approach enables a unique platform for investigation of the cancer-bone interface at metastasis. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Nanotechnology, Composites |