About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
BioNano Interfaces and Engineering Applications
|
| Presentation Title |
Gingerol and EGCG Enhance Osteogenic and Antibacterial Properties of Ag-doped CaP Bone Grafts |
| Author(s) |
Yongdeok Jo, Susmita Bose |
| On-Site Speaker (Planned) |
Yongdeok Jo |
| Abstract Scope |
As the world’s elderly population continues to grow rapidly, the number of orthopedic implant surgeries is increasing. During surgical intervention, the invasion of infectious agents frequently causes implant-related osteomyelitis. Antibiotics have been used to combat osteomyelitis in orthopedic applications. However, the high dose requirement, toxicity, and risk of treatment resistance have prompted interest in alternative multi-functionalized delivery systems with antibacterial and osteogenic properties. Silver (Ag) has provided antimicrobial properties to various microorganisms. E Epigallocatechin gallate (EGCG), the active compound in green tea leaves, and gingerol, a therapeutic compound extracted from ginger root, have shown the ability to enhance osteogenic properties and antibacterial properties. Our goal is to fabricate Ag-doped calcium phosphate (CaP) bone grafts with EGCG and gingerol to improve bone healing while providing infection prevention. Multifunctional Ag-doped CaP grafts with EGCG and gingerol have shown in vitro antibacterial properties to Staphylococcus aureus while enhancing in vitro osteoblast cellular activity. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Ceramics, Composites |