| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Characterization of Materials through High Resolution Coherent Imaging
|
| Presentation Title |
Imaging Intact Human Organs across the Scales using Hierarchical Phase-contrast Tomography |
| Author(s) |
Peter D. Lee, Claire Walsh, Paul Tafforeau, Christopher Werlein, Danny Jonigk, Maximilian Ackermann |
| On-Site Speaker (Planned) |
Peter D. Lee |
| Abstract Scope |
Biological organisms, like many materials, are hierarchically structured, spanning from molecules to whole organs via cells and organotypic units. For humans these scales span from the nanometre to the metre, and although there have been significant advances in imaging at both extremes, there is a gap in imaging techniques to span the scale from histology (micron) to clinical CT/MRI (100’s of microns). Using the exceptional coherence and high energy provided by the European Synchrotron Research Facility’s Extremely Bright Source (ESRF-EBS) upgrade to a 4th generation source, we’ve developed a technique that decouples resolution from specimen size. This technique, Hierarchical Phase-Contrast Tomography (HiP-CT), can achieve local cellular resolution of soft-tissues using phase propagated information. Specifically, 1 um voxels were achieved locally in a range of intact 150 mm diameter human organs, including the brain, heart, lung, kidney and spleen. The same techniques are applicable to materials see Human-Organ-Atlas.esrf.eu. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Characterization, Biomaterials, |