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Meeting MS&T22: Materials Science & Technology
Symposium 3D Printing of Biomaterials and Devices
Presentation Title Interlocked Bone Scaffolds with BMP Induced Osteogenesis with Use of 3D Printed Molds
Author(s) Kalpana S. Katti, Krishna Kundu, Sharad V Jaswandkar, Dinesh R Katti
On-Site Speaker (Planned) Kalpana S. Katti
Abstract Scope An estimated four million bone grafting procedures are performed worldwide each year. Currently, therapies for non-union bone defects are limited. We report development of an interlocked BMP2 and BMP7 coated scaffold block-assembly using 3D printed molds. The interlocked block-assembly maintains high surface area while maintaining the scaffold's structural integrity. The BMPs coated scaffold blocks exhibit increased bone extracellular matrix (ECM) formation. Extended time (9-week) study on in-vitro bone regeneration using the BMPs coated interlocking scaffold blocks showed up to 120% increase in the elastic modulus indicating enhanced ECM formation. We report significant increase in the bone-related protein and osteogenesis related Wnt-factors in BMP coated scaffolds. The BMPs influence ECM formation much longer than the availability of the BMPs in culture-media suggesting that BMPs play a crucial role on initial stages of osteogenesis. Modular and manufacturable BMPs coated interlocking scaffolds made using 3D printed molds provides a novel bone regeneration system.


3-D Printing in Regenerative Engineering
3D Bioprinting with Engineered Living Materials for Advanced Biofabrication
3D Printing Integrated with Controlled Delivery for In Situ Tissue Engineering of Complex and Inhomogeneous Tissues from Endogenous Stem/Progenitor Cells
3D Printing of Nanomaterials-based Biomedical Electronics
3D Printing of Zonal-structured Scaffolds for Complex Tissue Engineering
3D Printing Strategies to Fabricate Complex Scaffolds for Tissue Engineering Applications
Additive Manufacturing Process Simulation of Polyetherimide Porous Scaffolds for Bone Tissue Engineering Applications
Biohybrid Functional Material Design by Engineered Peptides
C-1: Surface Treatment of Titanium by Alkali treatment and Magnesium Deposition for Orthopedic Application
Effect of Printing Parameters on 3D-printed Biodegradable Biopolymer-metal Composite Material
Effect of Sr2+ and Ca2+ ions on 3D printed Beta Tricalcium-Phosphate/Alginate Composite Scaffolds for Bone Tissue Engineering
Implant Optimization Guided by Biomimetic Insight
Interlocked Bone Scaffolds with BMP Induced Osteogenesis with Use of 3D Printed Molds
Laser-Based 3D Printing for Medical Applications
Mechanical and Electrical Properties of 3D Printed Wearable Structures
Periodic Cellular Ceramic Structures by Replication of Additive Manufactured Templates
Selective Artificial Neural Network by Targeted Delivery of Neuronal Cells Using Magnetically Controlled 3D Printed Microrobots
Sheet Lamination Additive Manufacturing (SLAM) – A Viable Approach to Resorbable 3D Constructs for Bone Tissue Engineering
Solvent Cast 3D Printing with Different Molecular Weight Polymers
The Regulatory Roles of the Substrate Microenvironment in Cancer Progression in Tissue Engineering Scaffolds

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