|About this Abstract
||MS&T22: Materials Science & Technology
||3D Printing of Biomaterials and Devices
||Effect of Sr2+ and Ca2+ ions on 3D printed Beta Tricalcium-Phosphate/Alginate Composite Scaffolds for Bone Tissue Engineering
||Shebin Tharakan, Sally Lee, Serin Ahn, Chris Mathew, Michael Hadjiargyrou, Azhar Ilyas
|On-Site Speaker (Planned)
Beta-Tricalcium Phosphate (β-TCP) is a bioceramic that is a Calcium Phosphate of Hydroxyapatite, a material commonly used for bone growth. While bioceramics are difficult to 3D print, when placed into composite materials they become printable. Here, we 3D printed β-TCP/Alginate composite scaffolds to evaluate the effect of Sr2+ and Ca2+ ions on their biomechanical properties (swelling, degradation, and Raman profiling). Results show that the presence of Sr2+ slowed down the degradation rate in physiological conditions, with Sr-doped scaffolds having a longer life-span and greater structural fidelity than the respective Ca-doped scaffolds. The Sr-doped scaffolds had greater overall swelling compared to the Ca-doped counterparts. The presence of β-TCP caused a decrease in swelling for Ca-doped scaffolds, likely due to the amount of volume it displaced per scaffold. Furthermore, the scaffold expansion data showed that the scaffolds enlarged up to 24 hours but saturated in size dimensions up to 7 days.