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Meeting MS&T22: Materials Science & Technology
Symposium 3D Printing of Biomaterials and Devices
Presentation Title The Regulatory Roles of the Substrate Microenvironment in Cancer Progression in Tissue Engineering Scaffolds
Author(s) Dinesh Katti, Sharad V Jaswandkar, Hanmant Gaikwad, Kalpana S. Katti
On-Site Speaker (Planned) Dinesh Katti
Abstract Scope The substrate microenvironment and mechanical cues influence cancer progression in in vitro systems. The presence of extracellular minerals modulates membrane proteins' conformation (such as integrin), resulting in signal transduction within the cells. Thus, cancer cell mechanobiology, influenced by cell-microenvironment interaction such as substrate stiffness and biochemical/topographic substrate properties, plays a vital role in cancer cell growth and metastasis. Our present AFM-based experimental study and finite element analysis-based computation study focuses on understanding the influence of physical features of the cellular environment, such as bonemimetic scaffold substrate stiffness, on the cancer cell's metastatic characteristics like cell adhesion. Our investigations on the cellular adhesion protein integrin (αVβ3) and the cellular cytoskeletal protein actin provide insight into their mechanical response, critical to cellular functions. Furthermore, the studies on integrin interaction with the nanoclay provide an insight into stem cell differentiation leading to bone tissue regeneration in scaffolds.


3-D Printing in Regenerative Engineering
3D Bioprinting with Engineered Living Materials for Advanced Biofabrication
3D Printing Integrated with Controlled Delivery for In Situ Tissue Engineering of Complex and Inhomogeneous Tissues from Endogenous Stem/Progenitor Cells
3D Printing of Nanomaterials-based Biomedical Electronics
3D Printing of Zonal-structured Scaffolds for Complex Tissue Engineering
3D Printing Strategies to Fabricate Complex Scaffolds for Tissue Engineering Applications
Additive Manufacturing Process Simulation of Polyetherimide Porous Scaffolds for Bone Tissue Engineering Applications
Biohybrid Functional Material Design by Engineered Peptides
C-1: Surface Treatment of Titanium by Alkali treatment and Magnesium Deposition for Orthopedic Application
Effect of Printing Parameters on 3D-printed Biodegradable Biopolymer-metal Composite Material
Effect of Sr2+ and Ca2+ ions on 3D printed Beta Tricalcium-Phosphate/Alginate Composite Scaffolds for Bone Tissue Engineering
Implant Optimization Guided by Biomimetic Insight
Interlocked Bone Scaffolds with BMP Induced Osteogenesis with Use of 3D Printed Molds
Laser-Based 3D Printing for Medical Applications
Mechanical and Electrical Properties of 3D Printed Wearable Structures
Periodic Cellular Ceramic Structures by Replication of Additive Manufactured Templates
Selective Artificial Neural Network by Targeted Delivery of Neuronal Cells Using Magnetically Controlled 3D Printed Microrobots
Sheet Lamination Additive Manufacturing (SLAM) – A Viable Approach to Resorbable 3D Constructs for Bone Tissue Engineering
Solvent Cast 3D Printing with Different Molecular Weight Polymers
The Regulatory Roles of the Substrate Microenvironment in Cancer Progression in Tissue Engineering Scaffolds

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