|About this Abstract
|MS&T22: Materials Science & Technology
|3D Printing of Biomaterials and Devices
|3D Printing Integrated with Controlled Delivery for In Situ Tissue Engineering of Complex and Inhomogeneous Tissues from Endogenous Stem/Progenitor Cells
|Solaiman Tarafder, Chang H. Lee
|On-Site Speaker (Planned)
3D printing is becoming a booming technology to fabricate scaffolds for tissue engineering and regenerative medicine, benefited by customized design, tunable internal microstructure and a wide range of applicable materials. We developed a microprecise spatiotemporal delivery system embedded in three-dimensional (3D)-printed scaffolds, enabling the delivery of multiple GFs to desired locations with sustained release and high spatial resolution. In vitro, spatially controlled delivery of GFs with a prolonged release, guided formation of multi-tissue interfaces. In vivo, these scaffolds promoted recruitment of endogenous tendon progenitor cells followed by integrative healing of tendon-to-bone interface. Our findings demonstrate the potential of in situ tissue engineering of multi tissue interfaces by endogenous progenitor cells. Our micro-precise spatiotemporal delivery system embedded in 3D printing may serve as an efficient tool to regenerate complex and inhomogeneous tissues.